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11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2
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DeCS
Descriptor
Inglés
:
11-beta-Hydroxysteroid Dehydrogenase Type 2
Descriptor
Español
:
11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 2
Descriptor
Portugués
:
11-beta-Hidroxiesteróide Desidrogenase Tipo 2
Categoría:
D08.811.682.047.436.174.600
Definición
Inglés
:
An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to
CORTISONE
. It is found predominantly in mineralocorticoid target
tissues
such as the
KIDNEY
;
COLON
;
SWEAT GLANDS
; and the
PLACENTA
. Absence of the enzyme leads to a fatal form of childhood
hypertension
termed, APPARENT MINERALOCORTICOID EXCESS
SYNDROME.
Combinados
Inglés
:
11-beta-Hydroxysteroid Dehydrogenase Type 2
/
deficiency
use
Mineralocorticoid Excess Syndrome, Apparent
Nota Histórica
Inglés
:
2004; for 11 BETA-HSD2 use 11 BETA-HYDROXYSTEROID DEHYDROGENASES (NM) 1992-2003
Calificadores Permitidos
Inglés
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Número del Registro:
38200
Identificador Único:
D043209
Ocurrencia en la BVS
:
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